Low risk of locoregional recurrence of primary breast carcinoma after treatment with a modification of the Halsted radical mastectomy and selective use of radiotherapy

Abstract INTRODUCTION: The present histologic and immunohistochemical prognostic markers of breast carcinoma do not effectively identify the subset of patients with poor prognosis. Y-Box binding protein 1 (YB1) is a novel biomarker which may identify and aid in targeted personalized therapy for such patients. MATERIALS AND METHODS: The study was conducted on histopathology specimens of 74 patients of breast carcinoma who had undergone modified radical mastectomy. YB1 immunohistochemistry (IHC) was performed on manual tissue microarray blocks (each having 15 cores). The YB1 expression was quantified in terms of “immunoreactive score” which was correlated with clinical parameters, hormone receptor status, and Her2neu overexpression by IHC. The Her2neu status of the equivocal cases was further evaluated by fluorescent in situ hybridization (FISH). RESULTS: YB1 was positive in 36/74 (48.6%) cases. On IHC and analysis by FISH, 25/74 (34%) cases had Her2neu overexpression. Estrogen receptor (ER) and progesterone receptor (PR) positivity was found in 42% and 36.5% cases, respectively. YB1 immunopositivity was negatively correlated with ER and PR expression, but showed a significant positive correlation with Her2neu expression. No correlation was found with other clinical parameters, tumor stage, and grade, except lymph node involvement, which showed a positive association with YB1 expression. Triple-negative breast carcinoma constituted 25.6% of the total cases, out of which 73.6% were YB1 positive. CONCLUSION: This study found that YB1 has an association with Her2neu expression. It may in future provide a therapeutic target in Her2neu overexpressing tumors.

Download Full-text

Comparison of immunohistochemistry by automated cellular imaging system (ACIS) versus fluorescence in-situ hybridization in the evaluation of HER-2/neu expression in primary breast carcinoma

Histopathology ◽

10.1111/j.1365-2559.2005.02322.x ◽

2006 ◽

Vol 48 (3) ◽

pp. 258-267 ◽

Cited By ~ 45

Author(s):

O W Tawfik ◽

B F Kimler ◽

M Davis ◽

J K Donahue ◽

D L Persons ◽

...

Keyword(s):

In Situ Hybridization ◽

Breast Carcinoma ◽

Fluorescence In Situ Hybridization ◽

Imaging System ◽

Cellular Imaging ◽

Primary Breast Carcinoma ◽

Her 2

Download Full-text

MYC is expressed in the stromal and epithelial cells of primary breast carcinoma and paired nodal metastases

Molecular and Clinical Oncology ◽

10.3892/mco.2015.526 ◽

2015 ◽

Vol 3 (3) ◽

pp. 506-514

Author(s):

FIORITA GONZALES LOPES MUNDIM ◽

FATIMA SOLANGE PASINI ◽

MARIA MITZI BRENTANI ◽

FERNANDO AUGUSTO SOARES ◽

SUELY NONOGAKI ◽

...

Keyword(s):

Breast Carcinoma ◽

Epithelial Cells ◽

Primary Breast Carcinoma ◽

Nodal Metastases

Download Full-text

Correlation of pS2 expression of involved lymph nodes in relation to primary breast carcinoma

European Journal of Surgical Oncology ◽

10.1016/s0748-7983(95)90237-6 ◽

1995 ◽

Vol 21 (2) ◽

pp. 151-154 ◽

Cited By ~ 3

Author(s):

Paul H. Nichols ◽

Nassif B.N. Ibrahim ◽

C. James H. Padfield ◽

Simon J. Cawthorn

Keyword(s):

Breast Carcinoma ◽

Lymph Nodes ◽

Primary Breast Carcinoma

Download Full-text

PO-0954: Occult Primary Breast Carcinoma with axillary involvement: two different treatment approaches.

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)00972-5 ◽

2020 ◽

Vol 152 ◽

pp. S510

Author(s):

F. Sousa ◽

I. Azevedo ◽

D. Moreira ◽

B. Castro ◽

A. Laranja ◽

...

Keyword(s):

Breast Carcinoma ◽

Primary Breast Carcinoma ◽

Treatment Approaches

Download Full-text

Comparison of Outcome of one Versus two Drains Insertion for Seroma Formation Following Modified Radical Mastectomy in Breast Carcinoma

Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University ◽

10.48036/apims.v17i1.499 ◽

2021 ◽

Vol 17 (1) ◽

pp. 52-55

Author(s):

Shiraz Shaikh ◽

Ambreen Munir ◽

Shahnawaz Abro ◽

Shahida Khatoon ◽

Zameer Hussain Laghari ◽

...

Keyword(s):

Breast Carcinoma ◽

General Surgery ◽

Stable Condition ◽

Radical Mastectomy ◽

Seroma Formation ◽

University Hospital ◽

P Value ◽

Modified Radical Mastectomy ◽

Group A ◽

Group B

Objective: Comparative outcome of one versus two drains insertion for in the term of seroma formation following modified radical mastectomy in breast carcinoma. Methodology: This Prospective Interventional trial was conducted at Department of General Surgery, Liaquat University Hospital Hyderabad from February 2018 to January 2019. Females with breast carcinoma admitted for modified radical mastectomy were included. Patients were divided into two groups. Groups I underwent one drain placement and group II underwent two drains placement. All patients were observed to measure and record the volume of the fluid. Patients were discharged from Hospital in stable condition and after removal of drains, and followed up weekly for one month. Data was recorded on self-made proforma and analyzed by using SPSS-20. Results: Total of 80 patients were selected, 38 in group A and 42 in group B. Mean age of patients of group A was 49.08 ± 9.89 years and group B was 51.40 ± 13.59 years. , Excised Mass weight was lesser in group A as compared to group B. Mean volume of drain discharge was significantly higher in Group B 323.43 ± 158.88 ml, while it was in group A 230.29± 200.98, findings were statistically significant 0.013. Seroma formation was statistically insignificant among both groups as 8(21.1%) in group A and 10(23.8%) in group B, p-value 0.768. Conclusion: One-drain and two-drain insertion are equally effective to reduce the seroma formation after modified radical mastectomy; however, one drain insertion leads to more patient compliance and comfort with probably less morbidity and cost.

Download Full-text